Evaluation of anti-inflammatory and analgesic activities of extracts from herb of Chelidonium majus L.
PBN-AR
Instytucja
Instytut Włókien Naturalnych i Roślin Zielarskich
Informacje podstawowe
Główny język publikacji
en
Czasopismo
Central European Journal of Immunology
ISSN
1426-3912
EISSN
1644-4124
Wydawca
TERMEDIA PUBLISHING HOUSE LTD
DOI
Rok publikacji
2015
Numer zeszytu
4
Strony od-do
400-410
Numer tomu
40
Identyfikator DOI
Liczba arkuszy
Słowa kluczowe
en
LPS–induced rats
analgesic
anti-inflammatory
Chelidonium majus aqueous extract
non-protein fraction
protein enriched fraction
proinflammatory cytokines
mRNA.
Streszczenia
Język
en
Treść
The aim of the study was to evaluate analgesic activity (“hot plate” test), anti-inflammatory activity (carrageenan-induced paw edema) and locomotor activity in rats under the influence of three fractions of Chelidonium majus herb extract: full water extract (FWE), protein enriched fraction (PEF), and non-protein fraction (NPF). Effects of the fractions on the level of chosen cytokines and their mRNA levels were also assessed using lipopolysaccharide (LPS) administration as a proinflammatory cue. All fractions and diclofenac did not affect the locomotor activity of rats in comparison with the control group. FWE and PEF three hours after administration showed statistically significant analgesic activities comparable to morphine (p < 0.05). A slight reduction in rat paw edema was observed after three (comparable with diclofenac) and six hours in the NPF group. FWE revealed a statistically significant pro-inflammatory effect after three hours in comparison with the control group. Peripheral IL-1 and IL-4 cytokine concentrations were reduced under FWE and NPF, PEF fractions. The combination of FWE, PEF and NPF together with LPS showed only the effects of LPS. We suggest that protein enriched fraction (PEF) produced centrally mediated (morphine-like) analgesic action, whereas the anti-inflammatory potential was shown only after LPS-induced inflammation. The precise mechanisms involved in the production of anti-nociceptive and anti-inflammatory responses of studied fractions are not completely understood, but they may be caused rather by the presence of protein more than alkaloids-enriched fraction. This fraction of the extract could be used as an alternative therapy for the prevention of inflammatory-related diseases in the future, but further studies are needed.
Cechy publikacji
Medycyna
Nauki farmaceutyczne
Medicine
Pharmacy
discipline:Biochemia – dziedzina nauk biologicznych
discipline:Medycyna
discipline:Biochemistry – field of biological sciences
discipline:Medicine
Original article
Original article presents the results of original research or experiment.
Oryginalny artykuł naukowy
Oryginalny artykuł naukowy przedstawia rezultaty oryginalnych badań naukowych lub eksperymentu.
Inne
System-identifier
PBN-R:692807
CrossrefMetadata from Crossref logo
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