A tubular polycaprolactone/hyaluronic acid scaffolds for nasal cartilage tissue engineering
PBN-AR
Instytucja
Wydział Inżynierii Materiałowej i Ceramiki (Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie)
Informacje podstawowe
Główny język publikacji
EN
Czasopismo
Inżynieria Biomateriałów = Engineering of Biomaterials (7pkt w roku publikacji)
ISSN
1429-7248
EISSN
Wydawca
Wydawnictwo Naukowe AKAPIT
DOI
Rok publikacji
2017
Numer zeszytu
141
Strony od-do
8--12
Numer tomu
20
Identyfikator DOI
Liczba arkuszy
0.35
Autorzy
(liczba autorów: 4)
Pozostali autorzy
+ 3
Słowa kluczowe
EN
electrospinning
PCL
tissue engineering scaffolds
nasal cartilages
hydraulic acid
Streszczenia
Język
EN
Treść
In this preliminary study, 3D nanofibrous porous scaffolds in the form of spiral tubes for future application as nasal cartilages implants were fabricated by combining polycaprolactone electrospun fibers with drug modified hyaluronic acid gel. It is expected that the spiral form of the scaffold with open geometries, large surface area, and distance between the scaffold walls will be helpful for improving future cell penetration into the scaffolds, nutrient transport and metabolic waste removal, which are otherwise limited in conventional electrospun tissue-engineered scaffolds. The tubular scaffolds structure, its porosity and fibers’ diameter were assessed via scanning electron microscopy, and biological properties of the scaffolds were evaluated in an in vitro study using Simulated Body Fluid (SBF). SEM results showed that apatite formed within a short period on tubular scaffolds after its immersion in SBF, demonstrating high in vitro bioactivity of the scaffolds.
Cechy publikacji
original article
peer-reviewed
Inne
System-identifier
idp:112210