Phospholipid-protein balance in affective disorders: analysis of human blood serum using Raman and FTIR spectroscopy. A pilot study
PBN-AR
Instytucja
Instytut Fizyki Jądrowej im. Henryka Niewodniczańskiego Polskiej Akademii Nauk
Informacje podstawowe
Główny język publikacji
en
Czasopismo
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
ISSN
0731-7085
EISSN
Wydawca
DOI
URL
Rok publikacji
2016
Numer zeszytu
Strony od-do
287-296
Numer tomu
131
Identyfikator DOI
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Autorzy
Pozostali autorzy
+ 5
Słowa kluczowe
en
affective disorders
serum markers
Raman spectroscopy
FTIR
phospholipid &#8722
protein balance
depression
Streszczenia
Język
en
Treść
Raman and FTIR (Fourier Transform Infra Red) spectroscopies provide information on the chemical structure of compounds through identification and analysis of functional groups. In the present study, both spectroscopic techniques were used for investigating the phospholipid − protein balance in blood serum of depressed subjects (major depressive disorder and bipolar disorder type I or II) taking also into account their age and gender. The obtained results were compared with those of healthy subjects. The Raman and FTIR (using ATR (Attenuated Total Reflectance) technique), spectra show that a correlation exists between the level of phospholipids and proteins. Indeed, in depressed subjects the quantity of phospholipids and proteins is lower, compared to healthy ones. The second derivative of FTIR spectra shows that phospholipids directly affect the structure of proteins and their functions. In all male depressed subjects a higher amount of phospholipids and proteins compared to female depressed subjects was measured, offering them faster recovery perspectives. Spectroscopy results show that the phospholipids’ and proteins’ level is lower in depressed subjects from 41-65 compared to the age group between 20–40, independently from the gender. Consequently, this study shows that Raman and infrared spectroscopies might be applied as a diagnostic tool to evaluate the balance between phospholipids and proteins in blood serum as a potential biomarker in depressive disorders.
Cechy publikacji
peer-reviewed
original-article
Inne
System-identifier
25970
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