Ca:Mg:Zn:$CO_{3}$ and Ca:Mg:Zn:$CO_{3}$-tri- and bi-elemental carbonate microparticles for novel injectable self-gelling hydrogel-microparticle composites for tissue regeneration
PBN-AR
Instytucja
Wydział Inżynierii Materiałowej i Ceramiki (Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie)
Informacje podstawowe
Główny język publikacji
EN
Czasopismo
Biomedical Materials (30pkt w roku publikacji)
ISSN
1748-6041
EISSN
1748-605X
Wydawca
Institute of Physics Publishing
DOI
Rok publikacji
2017
Numer zeszytu
2
Strony od-do
1--12
Numer tomu
12
Link do pełnego tekstu
Identyfikator DOI
Liczba arkuszy
0.85
Autorzy
Pozostali autorzy
+ 16
Słowa kluczowe
EN
composite
zinc
magnesium
hydrogel
carbonate
gellan gum
injectable
Streszczenia
Język
EN
Treść
Injectable composites for tissue regeneration can be developed by dispersion of inorganic microparticles and cells in a hydrogel phase. In this study, multifunctional carbonate microparticles containing different amounts of calcium, magnesium and zinc were mixed with solutions of gellan gum (GG), an anionic polysaccharide, to form injectable hydrogel-microparticle composites, containing Zn, Ca and Mg. Zn and Ca were incorporated into microparticle preparations to a greater extent than Mg. Microparticle groups were heterogeneous and contained microparticles of differing shape and elemental composition. Zn-rich microparticles were 'star shaped' and appeared to consist of small crystallites, while Zn-poor, Ca-and Mg-rich microparticles were irregular in shape and appeared to contain lager crystallites. Zn-free microparticle groups exhibited the best cytocompatibility and, unexpectedly, Zn-free composites showed the highest antibacterial activity towards methicilin-resistant Staphylococcus aureus. Composites containing Zn-free microparticles were cytocompatible and therefore appear most suitable for applications as an injectable biomaterial. This study proves the principle of creating bi-and tri-elemental microparticles to induce the gelation of GG to create injectable hydrogel-microparticle composites.
Cechy publikacji
original article
peer-reviewed
Inne
System-identifier
idp:105841
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