CNS Metastases from Bone and Soft Tissue Sarcomas in Children, Adolescents, and Young Adults: Are They Really So Rare?
PBN-AR
Instytucja
Instytut Matki i Dziecka
Informacje podstawowe
Główny język publikacji
angielski
Czasopismo
BioMed Research International (Journal of Biomedicine and Biotechnology) (25pkt w roku publikacji)
ISSN
2314-6133
EISSN
Wydawca
Hindawi Publishing Corporation
DOI
Rok publikacji
2017
Numer zeszytu
1456473
Strony od-do
1-9
Numer tomu
2017
Identyfikator DOI
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Słowa kluczowe
angielski
CNS metastases
brain cord
spinal cord
bone tissue sarcomas
soft tissue sarcomas
children
adolescents
young adults
magnetic resonance imaging
MRI
computed tomography
Open access
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Creative Commons — Uznanie autorstwa
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Razem z publikacją
Streszczenia
Język
angielski
Treść
Purpose. To check whether primary involvement of brain/spinal cord by bone/soft tissue sarcomas’ metastases in children is as rare as described and to present various morphological forms of bone/soft tissue sarcomas’ CNS metastases. Methods. Patients with first diagnosis in 1999–2014 treated at single center were included with whole course of disease evaluation. Brain/spinal canal magnetic resonance imaging (MRI)/computed tomography were performed in cases suspicious for CNS metastases. Extension from skull/vertebral column metastases was excluded. Results. 550 patients were included. MRI revealed CNS metastases in 19 patients (incidence 3.45%), 14 boys, aged 5–22 years. There were 12/250 osteosarcoma cases, 2/200 Ewing’s sarcoma, 1/50 chondrosarcoma, 3/49 rhabdomyosarcoma (RMS), and 1/1 malignant mesenchymoma. There were 10 single metastases and 7 cases of multiple ones; in 2 RMS cases only leptomeningeal spread in brain and spinal cord was found. Calcified metastases were found in 3 patients and hemorrhagic in 4. In one RMS patient there were numerous solid, cystic, hemorrhagic lesions and leptomeningeal spread. Conclusions. CNS metastases are rare and late in children with bone/soft tissue sarcomas, although in our material more frequent (3.45%) than in other reports (0.7%). Hematogenous spread to brain and hemorrhagic and calcified lesions dominated in osteosarcoma. Ewing sarcoma tended to metastasize to skull bones. Soft tissue sarcomas presented various morphological forms.
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artykuł w czasopiśmie zagranicznym
oryginalny artykuł naukowy
publikacja recenzowana
research article
Inne
System-identifier
PX-59ccfac5d5dee10f16a9cab3
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