Pemetrexed conjugated with gold nanoparticles – synthesis, characterization and a study of noncovalent interactions
PBN-AR
Instytucja
Sieć Badawcza Łukasiewicz - Instytut Farmaceutyczny
Informacje podstawowe
Główny język publikacji
angielski
Czasopismo
European Journal of Pharmaceutical Sciences (35pkt w roku publikacji)
ISSN
0928-0987
EISSN
Wydawca
ELSEVIER SCIENCE BV
DOI
URL
Rok publikacji
2017
Numer zeszytu
Strony od-do
13-20
Numer tomu
109
Identyfikator DOI
Liczba arkuszy
Słowa kluczowe
angielski
AuNPs‑gold nanoparticles
Nanocomposites
PE-pemetrexed
Powder diffraction
Raman spectroscopy
Thermogravimetry
Transmission electron microscopy
Streszczenia
Język
angielski
Treść
Gold nanoparticles (AuNPs) have been widely used as nanocarriers in drug delivery application. However, the binding mechanism between AuNPs and drug bases still remains a puzzle. Our study included: (i) optimization of three synthesis of the AuNPs-pemetrexed (PE) nanocomposites formation which was monitored by UV-Vis spectroscopy, (ii) identification of PE in gold nanocomposites and mechanism of PE interaction with gold nanoparticles by electrochemistry, NMR and Raman measurements, (iii) characterization of the three nanocomposites by TEM, DSL, ESL, zeta potential, XRPD and TGA analysis. The obtained nanocomposites are homogeneously shaped and have a maximum diameter of around 14nm and 88nm, as measured by the TEM and DSL techniques, respectively. The zeta potential of the nanocomposites is -43mV and suggests a high stability of the nanoparticles and lower toxicity for the normal cells. Quantum chemical calculations were also performed on model systems to estimate the strength of the AuNPs-PE interaction. Taking into account the experimental and theoretical data a mechanism of the nanocomposites' formation has been proposed in which PE interacts with the gold surface by the COOH/COO- group.
Inne
System-identifier
PX-59a70100d5decf2a9c0c39eb
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