EMT promoting transcription factors as prognostic markers in human breast cancer
PBN-AR
Instytucja
Instytut Medycyny Wsi im. Witolda Chodźki
Informacje podstawowe
Główny język publikacji
en
Czasopismo
ARCHIVES OF GYNECOLOGY AND OBSTETRICS (20pkt w roku publikacji)
ISSN
0932-0067
EISSN
1432-0711
Wydawca
SPRINGER HEIDELBERG
DOI
URL
Rok publikacji
2017
Numer zeszytu
4
Strony od-do
817-825
Numer tomu
295
Identyfikator DOI
Liczba arkuszy
1,5
Autorzy
Pozostali autorzy
+ 1
Słowa kluczowe
en
Breast cancer
Epithelial–mesenchymal transition;
Prognostic markers
Transcription factors
Streszczenia
Język
en
Treść
PURPOSE: Breast cancer is one of the most common female cancers. Moreover, despite the progress in medicine, its mortality rate is still very high. Therefore, researchers are constantly looking for new prognostic factors, which may simplify disease diagnosis and optimize the therapy. Metastases are responsible for the majority of deaths caused by breast cancer. Epithelial-mesenchymal transition is one of the mechanisms of metastasis, which is controlled by specific transcription factors. In the recent years, many researchers studied the prognostic value of factors promoting the epithelial-mesenchymal transition in patients with breast cancer. This work is an attempt to summarize the current state of knowledge on this issue. METHODS: A systemic search of peer-reviewed articles published between November 2005 and February 2016 was performed using PubMed/MEDLINE database. Most cited articles constituted original papers, although single review articles were also included. RESULTS: Based on the so far conducted studies, a promising conclusion can be drawn, that several described factors might serve as a putative negative prognostic marker in breast cancer. CONCLUSIONS: Obtained results of this review should encourage researchers to conduct further clinical trials on large patient groups which will evaluate the prognostic value of EMT transcription factors in breast cancer course.
Cechy publikacji
Review article
Review article is a summarization of the current state of the research on a particular subject.
Artykuł przeglądowy
Artykuł przeglądowy stanowi podsumowanie aktualnego stanu badań w danym obszarze tematycznym.
Inne
System-identifier
PBN-R:826868
CrossrefMetadata from Crossref logo
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