Late-onset hypogonadism in men with systolic heart failure: prevalence, clinical associates, and impact on long-term survival
PBN-AR
Instytucja
Wydział Fizjoterapii (Akademia Wychowania Fizycznego we Wrocławiu)
Informacje podstawowe
Główny język publikacji
en
Czasopismo
ESC Journal of Heart Failure
ISSN
2055-5822
EISSN
Wydawca
The Heart Failure Association of the European Society of Cardiology / John Wiley & Sons Ltd
DOI
Rok publikacji
2014
Numer zeszytu
1
Strony od-do
41-51
Numer tomu
1
Identyfikator DOI
Liczba arkuszy
1,2
Słowa kluczowe
en
heart failure
male ageing
testosterone
sexual symptoms
late-onset hyp ogonadism
Streszczenia
Język
en
Treść
Backgroun d Male ageing is characterized by diminished circulatingandrogens with several adverse psychosomatic consequences and can beaggravated by concomitant chronic diseases. According to the European MaleAging Study (EMAS) Group, late-onset hypogonadism (LOH) refers totestosterone deficiency accompanied by sexual complaints.Aim We investigated the prevalence of LOH in men with systolic heart failure(HF), and its clinical determinants and prognostic consequences.Methods Among 201 men with systolic HF (age: 60 ± 11 years), serum totaltestosterone (TT) was assessed using an immunoassa y, and estimated free testos-terone (eFT) was calculated using Vermeulen’sformula.LOHwasdiagnosedwhenTT < 3.2 ng/mL and eFT < 64pg/mLwereaccompaniedbythreesexualsymptoms(decrease in the number of morning erections, reduced potency, and low libido) ofat least moderate sev erity assessed using the Aging Males’ Sympt oms Scale.Results Decreased frequency of morning erections, reduced potency, andlow libido were experienced by 56%, 62%, and 55% of men with HF,respectively; whereas 67%, 61%, and 44% of subjects complained of at leastone, two, and three symptoms, respectively. Hypogonadal TT and eFT wereobserved in 34% and 47% of patients, respectively; and in 33% subjects, bothTT and eFT were reduced. Finally, 30 men with HF (15%) were diagnosed withLOH as compared with 2% in a European male population (EMAS). In amultivariable model, older age and higher serum uric acid were independentlyassociated with greater LOH prevalence (both P < 0.05). Among men aged≤60 years (but not in those aged >60 years), LOH increased 5-year all-causemortality in the univariable model; however, when adjusted for HF severity,the association lost its statistical significance.Conclusions Men with systolic HF commonly report sexual complaints.LOH—the combination of sexual dysfunction and testosterone deficiency—occurs more frequently t han in a general male population. LOH does notaffect long-term mortality, when adjusted for HF severity.
Cechy publikacji
Original article
Original article presents the results of original research or experiment.
Oryginalny artykuł naukowy
Oryginalny artykuł naukowy przedstawia rezultaty oryginalnych badań naukowych lub eksperymentu.
Inne
System-identifier
PBN-R:758413
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