Iron in typical and atypical parkinsonism – Mössbauer spectroscopy and MRI studies
PBN-AR
Instytucja
Wydział Fizyki (Politechnika Warszawska)
Informacje podstawowe
Główny język publikacji
en
Czasopismo
Hyperfine Interactions
ISSN
0304-3843
EISSN
Wydawca
Springer Netherlands
DOI
Rok publikacji
2016
Numer zeszytu
1
Strony od-do
1-8
Numer tomu
237
Identyfikator DOI
Liczba arkuszy
0.5
Autorzy
Pozostali autorzy
+ 3
Słowa kluczowe
en
Brain iron; MRI relaxation times; Mössbauer spectroscopy; Parkinsonism
Streszczenia
Język
en
Treść
Iron may play important role in neurodegeneration. The results of comparative studies of human brain areas (control and pathological) performed by Mössbauer spectroscopy (MS) and magnetic resonance imaging (MRI) techniques are presented. Mössbauer spectroscopy demonstrated a higher concentration of iron in atypical parkinsonism (progressive supranuclear palsy PSP) in the brain areas Substantia Nigra (SN) and Globus Pallidus (GP) involved in this pathological process, compared to control, while the concentration of iron in pathological tissues in typical parkinsonism (Parkinson’s disease - PD) did not differ from that in control. These results were compared with the changes in 1/T1 and 1/T2 (T1 and T2 being the relaxation times determined by MRI). A good linear correlation curve was found between the concentration of iron as determined by MS in different areas of control human brains and between 1/T1 and 1/T2. Whereas the finding in PSP-GP (the brain area involved in PSP) also fitted to such a correlation, this was not so for the correlation between pathological SN – the brain area involved in both diseases – and 1/T2, indicating a dependence of T2 on other factors than just the concentration of iron. © 2016, The Author(s).
Inne
System-identifier
WUTd4d420945341492bb117ca2ea099f148
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