Comprehensive Spectroscopic Characteryzation of Finasteride Polymorphic Forms. Does the Form X Exist?
PBN-AR
Instytucja
Instytut Chemii Fizycznej Polskiej Akademii Nauk
Informacje podstawowe
Główny język publikacji
en
Czasopismo
JOURNAL OF PHARMACEUTICAL SCIENCES
ISSN
0022-3549
EISSN
1520-6017
Wydawca
WILEY-BLACKWELL
DOI
URL
Rok publikacji
2015
Numer zeszytu
Strony od-do
1650-1657
Numer tomu
104
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Autorzy
(liczba autorów: 8)
Pozostali autorzy
+ 6
Słowa kluczowe
en
finasteride
polymorphism
FTIR (Fourier transform infrared spectroscopy)
Calorimetry (DSC)
solid-state NMR
X-ray powder diffractometry
chirality
circular dichroism
Streszczenia
Język
en
Treść
The pure polymorphic forms I, II, and III of finasteride were prepared and their purity was confirmed by FTIR, differential scanning calorimetry, and X-ray powder diffraction measurements. The preparation experiments demonstrated that the desolvation process of some finasteride solvates does result not only in the formation of polymorphic forms I and II, but also in obtaining the pure form III. The 13C cross-polarization magic angle spinning (CP-MAS) and the 15N CP-MAS spectra can distinguish all three polymorphic forms of finasteride. Additionally, the data point to the presence of only one molecule in crystallographic asymmetric unit of polymorphic forms I and III and two molecules in the form II. The application of electronic circular dichroism (ECD) and vibrational circular dichroism (VCD) spectroscopy for finasteride polymorphic forms shows that the three polymorphs could be distinguished by the characteristic shapes of their VCD spectra in the spectral range 1520–1440 cm–1. The ECD spectral patterns of all these forms, however, are almost indistinguishable because of their close similarity. Comparison of the 13C CP-MAS spectra of forms I, II, and III with those reported in the literature indicates that the so-called finasteride “form X” is identical to the previously known finasteride form III. On this basis, the existence of form X was excluded. © 2015 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 104:1650–1657, 2015
Cechy publikacji
ORIGINAL_ARTICLE
Inne
System-identifier
581996
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