Progression of hypertension and kidney disease in aging fawn-hooded rats is mediated by enhanced influence of renin-angiotensin system and suppression of nitric oxide system and epoxyeicosanoids
PBN-AR
Instytucja
Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk
Informacje podstawowe
Główny język publikacji
en
Czasopismo
CLINICAL AND EXPERIMENTAL HYPERTENSION
ISSN
1064-1963
EISSN
Wydawca
INFORMA HEALTHCARE
DOI
URL
Rok publikacji
2016
Numer zeszytu
7
Strony od-do
644-651
Numer tomu
38
Identyfikator DOI
Liczba arkuszy
0.80
Słowa kluczowe
en
Angiotensin II
chronic kidney disease
fawn-hooded rat
hypertension
proteinuria
Streszczenia
Język
en
Treść
The fawn-hooded hypertensive (FHH) rat serves as a genetic model of spontaneous hypertension associated with glomerular hyperfiltration and proteinuria. However, the knowledge of the natural course of hypertension and kidney disease in FHH rats remains fragmentary and the underlying pathophysiological mechanisms are unclear. In this study, over the animals' lifetime, we followed the survival rate, blood pressure (telemetry), indices of kidney damage, the activity of renin-angiotensin (RAS) and nitric oxide (NO) systems, and CYP450-epoxygenase products (EETs). Compared to normotensive controls, no elevation of plasma and renal RAS was observed in prehypertensive and hypertensive FHH rats; however, RAS inhibition significantly reduced systolic blood pressure (137 +/- 9 to 116 +/- 8, and 159 +/- 8 to 126 +/- 4 mmHg, respectively) and proteinuria (62 +/- 2 to 37 +/- 3, and 132 +/- 8 to 87 +/- 5 mg/day, respectively). Moreover, pharmacological RAS inhibition reduced angiotensin (ANG) II and increased ANG 1-7 in the kidney and thereby may have delayed the progression of kidney disease. Furthermore, renal NO and EETs declined in the aging FHH rats but not in the control strain. The present results, especially the demonstration of exaggerated vascular responsiveness to ANG II, indicate that RAS may contribute to the development of hypertension and kidney disease in FHH rats. The activity of factors opposing the development of hypertension and protecting the kidney declined with age in this model. Therefore, therapeutic enhancement of this activity besides RAS inhibition could be attempted in the therapy of human hypertension associated with kidney disease.
Cechy publikacji
discipline:Medycyna
discipline:Nauki farmaceutyczne
discipline:Medicine
discipline:Pharmacy
Original article
Original article presents the results of original research or experiment.
Oryginalny artykuł naukowy
Oryginalny artykuł naukowy przedstawia rezultaty oryginalnych badań naukowych lub eksperymentu.
Inne
System-identifier
PBN-R:767611
CrossrefMetadata from Crossref logo
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