Different blood pressure responses to opioids in 3 rat hypertension models: role of the baseline status of sympathetic and renin-angiotensin systems
PBN-AR
Instytucja
Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk
Informacje podstawowe
Główny język publikacji
angielski
Czasopismo
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
ISSN
0008-4212
EISSN
Wydawca
CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
DOI
URL
Rok publikacji
2016
Numer zeszytu
11
Strony od-do
1159-1169
Numer tomu
94
Identyfikator DOI
Liczba arkuszy
1,00
Słowa kluczowe
angielski
arterial blood pressure
biphalin
morphine
peripheral vascular resistance
rat hypertension models
sympathetic nervous system
renin-angiotensin system
Streszczenia
Język
angielski
Treść
Opioids interact with sympathetic and renin-angiotensin systems in control of mean arterial pressure (MAP). Our earlier finding that biphalin, a synthetic enkephalin analogue, decreased MAP in anaesthetized spontaneously hypertensive rats (SHR) prompted us to further explore this action, to get new insights into pathogenesis of various forms of hypertension. Biphalin effects were studied in SHR, uninephrectomized rats on a high-salt diet (HS/UNX), and rats with angiotensin-induced hypertension (Ang-iH). Besides MAP, renal and iliac blood flows (RBF, IBF) and vascular resistances were measured. In anaesthetized and conscious SHR, biphalin (300 mu g.h(-1).kg(-1) i.v.) decreased MAP by similar to 10 and similar to 20 mm Hg, respectively (P < 0.001). In anaesthetized HS/UNX and normotensive rats, MAP increased by similar to 6-7 mm Hg (P < 0.02); without anaesthesia, only transient decreases occurred. MAP never changed in Ang-iH rats. Morphine (1.5 mg.h(-1).kg(-1) i.v.) decreased MAP in HS/UNX but only transiently so without anaesthesia; such anaesthesia dependence of response was also seen in normotensive rats. Ang-iH rats never responded to morphine. Hypotensive effect in SHR only depends primarily on the reduction by biphalin of vascular responsiveness to increased sympathetic stimulation; such increase is well documented for SHR. No MAP response to biphalin or morphine in Ang-iH could depend on angiotensin-induced alterations of the vascular wall morphology and function.
Cechy publikacji
discipline:Medycyna
discipline:Nauki farmaceutyczne
discipline:Medicine
discipline:Pharmacy
Original article
Original article presents the results of original research or experiment.
Oryginalny artykuł naukowy
Oryginalny artykuł naukowy przedstawia rezultaty oryginalnych badań naukowych lub eksperymentu.
Inne
System-identifier
PBN-R:766474
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