Vitamin D receptor gene polymorphisms in Alzheimer's disease patients
PBN-AR
Instytucja
Wydział Lekarski Kształcenia Podyplomowego (Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu)
Informacje podstawowe
Główny język publikacji
en
Czasopismo
Experimental Gerontology
ISSN
0531-5565
EISSN
Wydawca
PERGAMON-ELSEVIER SCIENCE LTD
DOI
URL
Rok publikacji
2015
Numer zeszytu
Strony od-do
142-147
Numer tomu
69
Identyfikator DOI
Liczba arkuszy
Słowa kluczowe
en
AD
VDR polymorphism
Streszczenia
Język
en
Treść
The aim The aim of this study was to determine whether polymorphisms of the VDR gene may increase the risk of Alzheimer disease (AD) development in Lower Silesian patients in comparison with other populations. Material and methods 108 AD patients (aged 73.7 ± 8.6) vs 77 healthy volunteers (aged 64.5 ± 7.8) in the Lower Silesian population were studied. We investigated the frequency of the VDR polymorphisms rs731236 (TaqI), rs7975232 (ApaI), rs10735810 (FokI) and rs1544410 (BsmI) in the AD group vs the healthy group. Afterwards, MEDLINE and ResearchGate were studied to compare our investigation with other populations, due to the relatively small group size in our study. Results We did not observe any significant differences in frequency of genotypes of rs731236 (TaqI), rs10735810 (FokI) or rs1544410 (BsmI) VDR polymorphisms between the two Lower Silesian groups. Frequency of allele A of ApaI in the control group was significantly higher vs AD patients (p < 0.0177) in the Lower Silesian population. Furthermore the difference in the occurrence of allele t in TaqI and allele A in ApaI between AD patients vs the control group was significant (respectively p < 0.0056, p < 0.0140) in British Europeans. This observation may suggest that allele “a” of the ApaI polymorphism is a risk allele in AD Lower Silesian patients. We compared our results with those obtained for the population of British Europeans. In multivariate stepwise regression, allele “A” of ApaI was associated with 30% lower risk of AD (OR = 0.70, p = 0.0009) in total treated Polish and British populations. We did not observe similar results in Turkish and Iranian populations. Conclusion Our data suggest that the allele “A” VDR genotype of ApaI reduces AD risk, probably depending on ethnic origin and climatic conditions.
Cechy publikacji
ORIGINAL_ARTICLE
Inne
System-identifier
580555
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