Prevalence and impact of autoimmune thyroid disease on myasthenia gravis course
PBN-AR
Instytucja
Wydział Psychologii (SWPS Uniwersytet Humanistycznospołeczny z siedzibą w Warszawie)
Informacje podstawowe
Główny język publikacji
en
Czasopismo
Brain and Behavior
ISSN
2162-3279
EISSN
Wydawca
DOI
URL
Rok publikacji
2016
Numer zeszytu
e00537
Strony od-do
1-6
Numer tomu
Identyfikator DOI
Liczba arkuszy
0.3
Autorzy
(liczba autorów: 8)
Pozostali autorzy
+ 7
Słowa kluczowe
en
autoimmune thyroid diseases
Graves' disease
Hashimoto's thyroiditis
myasthenia gravis
Streszczenia
Język
en
Treść
Objectives: Autoimmune thyroid diseases (ATDs) frequently accompany myasthenia gravis (MG) and may influence its course. We aimed to determine the association and impact of ATD with early-(< 50 years), late-onset MG, or thymoma-MG. Materials and Methods: Prevalence of ATD was measured in a cross-sectional study of 343 consecutive patients with MG (236 F, 107 M) aged 4–89 years; 83.8% were seropositive, in 2.9%, anti-MuSK antibodies were detected. Concentrations of antithyroid peroxidase antibodies, antithyroglobulin antibodies, antithyrotropin receptor antibodies, and TSH level were measured in all patients. MG clinical course, treatment received, and treatment results were evaluated. Results: Autoimmune thyroid diseases were diagnosed in 92 (26.8%) of MG patients including 4.4% with Graves (GD), 9% with Hashimoto thyroiditis (HT), and 13.4% with antithyroid antibodies only. GD patients had ocular symptoms more often than patients with antithyroid antibodies or HT (p = .008). ATD prevalence was comparable in MG with early and late onset, while non-ATDs were more frequent in thymoma-MG (p = .049). Immunosuppressive therapy was less frequently needed in the patients with MG and ATD, indirectly indicating milder MG course (p = .005). Risk of myasthenic crisis and the results of treatment did not differ between patients with and without ATD. Conclusions: Autoimmune thyroid diseases are frequently accompanied by early-and late-onset MG, while thymoma-MG is related to higher risk of non-ATD. Myasthenia coexisting with ATD follows milder course than MG alone.
Inne
System-identifier
SWPS6a17e2bff48446c99ddd0df5c35a1909
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