Radiation sterilization of anthracycline antibiotics in solid state.
PBN-AR
Instytucja
Sieć Badawcza Łukasiewicz - Instytut Biotechnologii i Antybiotyków
Informacje podstawowe
Główny język publikacji
angielski
Czasopismo
Scientific World Journal
ISSN
2356-6140
EISSN
1537-744X
Wydawca
Hindawi Publishing Corporation
DOI
URL
Rok publikacji
2013
Numer zeszytu
258758
Strony od-do
1-7
Numer tomu
2013
Identyfikator DOI
Liczba arkuszy
0,5
Słowa kluczowe
angielski
daunorubicin
doxorubicin
epirubicin
free radical
anthracycline
antiinfective agent
Anthracyclines
Anti-Bacterial Agents
Half-Life
Radiation
Ionizing
Sterilization
Streszczenia
Język
angielski
Treść
Abstract The impact of ionizing radiation generated by a beam of electrons of 25-400 kGy on the stability of such analogs of anthracycline antibiotics as daunorubicin (DAU), doxorubicin (DOX), and epidoxorubicin (EPI) was studied. Based on EPR results, it was established that unstable free radicals decay exponentially with the half-time of 4 days in DAU and DOX and 7 days in EPI after irradiation. Radiation-induced structural changes were analyzed with the use of spectrophotometric methods (UV-Vis and IR) and electron microscope imaging (SEM). A chromatographic method (HPLC-DAD) was applied to assess changes in the contents of the analogs in the presence of their impurities. The study showed that the structures of the analogs did not demonstrate any significant alterations at the end of the period necessary for the elimination of unstable free radicals. The separation of main substances and related substances (impurities and potential degradation products) allowed determining that no statistically significant changes in the content of particular active substances occurred and that their conversion due to the presence of free radicals resulting from exposure to an irradiation of 25 kGy (prescribed to ensure sterility) was not observed. © 2013 A. Kaczmarek et al.
Inne
System-identifier
PX-56b4ae4f8106eb718270077f
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