An endomorphine analog ([d-Ala2]-Endomorphin 2, TAPP) lowers blood pressure and enhances tissue nitric oxide in anesthetized rats
PBN-AR
Instytucja
Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk
Informacje podstawowe
Główny język publikacji
en
Czasopismo
Pharmacological Reports
ISSN
1734-1140
EISSN
Wydawca
Elsevier Sp. z o.o.
DOI
Rok publikacji
2016
Numer zeszytu
3
Strony od-do
616–619
Numer tomu
68
Identyfikator DOI
Liczba arkuszy
0,56
Słowa kluczowe
en
Synthetic opioid receptor agonist
Arterial blood pressure
Tissue nitric oxide
Renal hemodynamics
Streszczenia
Język
en
Treść
AbstractBackground Activation of opioid receptors can alter cardiovascular function, an action possibly mediated by nitric oxide (NO). In this study we examined the effects of ([d-Ala2]-Endomorphin 2, TAPP), a synthetic opioid μ-receptor agonist, on blood pressure (MABP), tissue NO bioavailability and renal hemodynamics and excretion. Methods In acute experiments with anesthetized normotensive male Sprague-Dawley rats TAPP was given as a short i.v. infusion at a dose of 1.2 or 12 mg/kg and then MABP, renal medullary NO signal (polarographic electrode), total renal blood flow (RBF, renal artery Transonic probe), renal regional perfusion (laser-Doppler fluxes) and renal excretion were simultaneously measured over 2 h. Results After 1.2 mg/kg dose MABP decreased progressively from 121 ± 7 to 114 ± 9 mmHg (−6%, p < 0.05) while kidney tissue NO signal increased from 29.1 ± 2.7 to 31.7 ± 3.1 nA (6%, p < 0.04). Both effects were prevented by Naloxone methiodide, a peripheral opioid receptor inhibitor. RBF and renal regional perfusion were not altered by either dose of TAPP; renal sodium excretion changes were highly variable and were not affected by Naloxone pretreatment. Conclusions Briefly, we found that in anesthetized normotensive rats stimulation of peripheral opioid receptors with TAPP caused a prolonged decrease in arterial pressure, a change that was associated and probably causally related to an increase in tissue NO. The data suggest that synthetic opioids that do not penetrate the blood–brain barrier and are potentially non-addictive could be considered for antihypertensive therapy.
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Komunikat o wynikach badań
Short communication
Inne
System-identifier
PBN-R:718989
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