Chronic but not acute antidepressant treatment alters serum zinc/copper ratio under pathological/zinc-deficient conditions in mice
PBN-AR
Instytucja
Wydział Inżynierii Materiałowej i Ceramiki (Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie)
Informacje podstawowe
Główny język publikacji
EN
Czasopismo
Journal of Physiology and Pharmacology
ISSN
0867-5910
EISSN
1899-1505
Wydawca
Polish Physiological Society
DOI
Rok publikacji
2014
Numer zeszytu
5
Strony od-do
673--678
Numer tomu
65
Link do pełnego tekstu
Identyfikator DOI
Liczba arkuszy
0.42
Autorzy
(liczba autorów: 6)
Pozostali autorzy
+ 5
Słowa kluczowe
EN
copper
depression
zinc deficiency
serum
oxidative stress
zinc/copper ratio
proinflammatory cytokines
antidepressant
Streszczenia
Język
EN
Treść
Depression is the leading psychiatric disorder with a high risk of morbidity and mortality. Clinical studies report lower serum zinc in depressed patients, suggesting a strong link between zinc and mood disorders. Also copper as an antagonistic element to zinc seems to play a role in depression, where elevated concentration is observed. In the present study we investigated serum copper and zinc concentration after acute or chronic antidepressant (AD) treatment under pathological/zinc-deficient conditions. Zinc deficiency in mice was induced by a special diet administered for 6 weeks (zinc adequate diet – ZnA, contains 33.5 mgZn/kg; zinc deficient diet – ZnD, contains 0.2 mgZn/kg). Animals received acute or chronically saline (control), imipramine, escitalopram, reboxetine or bupropion. To evaluate changes in serum copper and zinc concentrations the total reflection X-ray fluorescence (TXRF) and flame atomic absorption spectrometry (FAAS) was performed. In ZnD animals serum zinc level was reduced after acute ADs treatment (similarly to vehicle treatment), however, as demonstrated in the previous study after chronic ADs administration no differences between both ZnA and ZnD groups were observed. Acute ADs in ZnD animals caused different changes in serum copper concentration with no changes after chronic ADs treatment. The calculated serum Zn/Cu ratio is reduced in ZnD animals (compared to ZnA subjects) treated with saline (acutely or chronically) and in animals treated acutely with ADs. However, chronic treatment with ADs normalized (by escitalopram, reboxetine or bupropion) or increased (by imipramine) this Zn/Cu ratio. Observed in this study normalization of serum Zn/Cu ratio in depression-like conditions by chronic (but not acute) antidepressants suggest that this ratio may be consider as a marker of depression or treatment efficacy. © 2014, Polish Physiological Society. All rights reserved.
Cechy publikacji
original article
peer-reviewed
Inne
System-identifier
idp:085949