Decreased serum zinc concentration during depressive episode in patients with bipolar disorder
PBN-AR
Instytucja
Wydział Inżynierii Materiałowej i Ceramiki (Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie)
Informacje podstawowe
Główny język publikacji
EN
Czasopismo
Journal of Affective Disorders
ISSN
0165-0327
EISSN
1573-2517
Wydawca
Elsevier
DOI
URL
Rok publikacji
2016
Numer zeszytu
Strony od-do
272--277
Numer tomu
190
Link do pełnego tekstu
Identyfikator DOI
Liczba arkuszy
0.42
Autorzy
(liczba autorów: 10)
Pozostali autorzy
+ 9
Słowa kluczowe
EN
depression
zinc
bipolar disorder
mania
remission
serum biomarkers
Streszczenia
Język
EN
Treść
Objectives: Zinc may be involved in the pathophysiology and treatment of depressive disorder. However, data on this issue in bipolar disorder (BD) are limited. The aim of the study was to assess zinc concentrations in the blood serum of patients at various phases and stages of bipolar disorder. Methods: The study included 129 patients with a diagnosis of bipolar disorder type I (n=69) or type II (n=60). Fifty-eight were in a depressive episode, 23 in a manic episode and 48 in remission. Fifty healthy volunteers made a control group. Zinc concentration was measured using flame atomic absorption spectrometry. Results: Serum zinc level in patients diagnosed with BD type I in the depressive phase was significantly reduced as compared with mania, remission and healthy subjects. In the BD type II, serum zinc level in hypomania, depression or remission phase was not significantly different from the control group. In the whole group, lower level of zinc in depression compared to remission and control subjects was found during late stage of the illness but not in the early stage. Zinc concentration was not dependent on the severity of manic or depressive symptoms and subtype of depression but correlated positively with the number of manic/hypomanic relapses in the past year. Limitations: Lack of prospective model, heterogeneity of pharmacological treatment, small number of subgroups presenting specified clinical features. Conclusions: Decreased serum zinc concentration occurs in depression in BD type I and probably in depression in the late stage of BD. (C) 2015 Elsevier B.V. All rights reserved.
Cechy publikacji
original article
peer-reviewed
Inne
System-identifier
idp:095159
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