New generation poly($\epsilon$-caprolactone)/gel-derived bioactive glass composites for bone tissue engineering. Pt. 1, Materials properties
PBN-AR
Instytucja
Wydział Inżynierii Materiałowej i Ceramiki (Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie)
Informacje podstawowe
Główny język publikacji
EN
Czasopismo
Materials Science and Engineering. C, Materials for Biological Applications
ISSN
0928-4931
EISSN
1873-0191
Wydawca
Elsevier Science BV
Rok publikacji
2015
Numer zeszytu
Strony od-do
9--21
Numer tomu
56
Link do pełnego tekstu
Identyfikator DOI
Liczba arkuszy
0.92
Autorzy
Pozostali autorzy
+ 1
Słowa kluczowe
EN
mechanical properties
biodegradation
biocompatibility
surface properties
solvent-cast films
polymer-ceramic composites
crystallinity
Streszczenia
Język
EN
Treść
Poly(ε-caprolactone) (PCL) based composite films containing 12 and 21 vol.% bioactive glass (SBG) microparticles were prepared by solvent casting method. Two gel-derived SBGs of SiO2-CaO-P2O5 system differing in SiO2 and CaO contents were applied (mol%): S2: 80SiO2, 16CaO, 4P2O5 and A2: 40SiO2, 54CaO, 6P2O5. The surfaces of the films in contact with Petri dish and exposed to the gas phase during casting were denoted as GS and AS, respectively. Both surfaces of films were characterised in terms of their morphology, micro- and nano-topography as well as wettability. Also mechanical properties (tensile strength, Young's modulus) and PCL matrix crystallinity (degree of crystallinity, crystal size) were evaluated. Degradation behaviour was examined by incubation of materials in UHQ-water at 37°C for 56 weeks. The crystallinity, melting temperature and mass loss of incubated materials and pH changes of water were monitored. Furthermore, proliferation of MG-63 osteoblastic cells by direct contact and cytotoxic effect of obtained materials were investigated. Results showed that opposite surfaces of the same polymer and composite films differ in studied surface parameters. The addition of SBG particles into PCL matrix improves nano- and micro-roughness of both surfaces, enhances the hydrophilicity of GS surfaces (∼67° for 21A2-PCL compared to ∼78° for pure PCL) and also makes AS surface more hydrophobic (∼94° for 21S2-PCL compared to ∼86° for pure PCL). The nucleation density of PCL was increased with increasing content of SBG particles, which results in the large number of fine spherulites on composite AS surfaces observed using polarized optical (POM), scanning electron (SEM), and atomic force (AFM) microscopies. Higher content of SBG particles causes a notable increase of Young's modulus (from 0.38 GPa for pure PCL, 0.90 GPa for 12A2-PCL to 1.31 GPa for 21A2-PCL), which also depends on SBG chemical composition. After 56-week degradation test, considerably higher crystallinity increase (Δχc ∼148% for 21S2-PCL, ∼81% for 21A2-PCL) and weight loss (∼17% for both) were found for composite materials, depending on SBG composition, in contrast to value variations for pure PCL film (Δχc ∼43%, weight loss ∼1.6%). Furthermore, it seems that both SBG could neutralize acidic degradation by-products of PCL at later incubation stages. Obtained SBG-PCL composites show excellent biocompatibility, support cell proliferation also may modulate cell response depending on the glass composition. The results indicate the possibility to use different contents and/or chemical compositions of SBG to obtain composite materials with various, but controlled, surface and mechanical properties as well as degradation kinetics. © 2015 Elsevier B.V. All rights reserved.
Cechy publikacji
original article
peer-reviewed
Inne
System-identifier
idp:089976
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