Effects of systemic administration of kynurenic acid and glycine on renal haemodynamics and excretion in normotensive and spontaneously hypertensivr rats
PBN-AR
Instytucja
Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk
Informacje podstawowe
Główny język publikacji
en
Czasopismo
European Journal of Pharmacology
ISSN
0014-2999
EISSN
Wydawca
ELSEVIER SCIENCE BV
DOI
URL
Rok publikacji
2014
Numer zeszytu
Strony od-do
37-41
Numer tomu
743
Identyfikator DOI
Liczba arkuszy
0,67
Słowa kluczowe
angielski
Renal haemodynamics
Renal excretion
Kynurenic acid
Glycine
Streszczenia
Język
angielski
Treść
Both NMDA receptor and kynurenic acid (KYNA), a glycine-site NMDA receptor antagonist, are present in the kidney yet their functional role remains unclear. Our aim was to examine effects of intravenous KYNA and glycine on arterial blood pressure (MAP) and renal haemodynamics and excretion in anaesthetized normotensive Sprague–Dawley (S–D) and in spontaneously hypertensive (SHR) rats. Renal blood flow (RBF, renal artery probe) and renal cortical (CBF) and outer- and inner medullary perfusion (laser-Doppler) were measured, along with diuresis (V) and sodium excretion (UNaV). KYNA given alone (150 mg kg−1 iv) or during infusion of glycine at 1 g kg−1 h−1 iv (G+K) increased or decreased RBF, respectively, in both S–D and SHR. Neither treatment altered MAP. In both strains glycine alone increased RBF and CBF 50–60% and was clearly diuretic and natriuretic, less so in SHR. KYNA increased UNaV by 4.1±1.7 μmol min−1and V by 11.1±4.3 μl min−1 in S–D (P<0.05 for both); the respective increases in SHR were by 1.7±0.6 μmol min−1 and 4.7±1.7 μl min−1 (P<0.02 for both). G+K treatment increased UNaV by 5.2±1.4 μmol min−1 (P<0.01) and V by 29.6±4.6 μmol min−1 (P<0.001) in S–D, and by 2.7±0.7 μmol min−1 (P<0.05) and 19.3±3.5 μl min−1 (P<0.0006) in SHR. In conclusion, KYNA increased renal excretion, apparently by inhibiting tubular reabsorption, whereas glycine substantially increased renal haemodynamics by an ill-defined mechanism, with a secondary increase in the excretion. Combined G+K treatment could be utilised to combat body fluid retention and possibly alleviate hypertension, without endangering renal perfusion and function.
Cechy publikacji
ORIGINAL_ARTICLE
Inne
System-identifier
589687
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