Effects of liposomes with polyisoprenoids, potential drug carriers, on the cardiovascular and excretory system in rats
PBN-AR
Instytucja
Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk
Informacje podstawowe
Główny język publikacji
en
Czasopismo
Pharmacological Reports
ISSN
1734-1140
EISSN
Wydawca
Elsevier Sp. z o.o.
DOI
Rok publikacji
2014
Numer zeszytu
2
Strony od-do
273-278
Numer tomu
66
Identyfikator DOI
Liczba arkuszy
0,80
Słowa kluczowe
en
Liposomes
Drug delivery
Polyisoprenoid alcohols
Renal toxicity
Renal morphology
Streszczenia
Język
en
Treść
Background: The unpredictable side effects of a majority currently used drugs are the substantial issue, in which patients and physicians are forced to deal with. Augmenting the therapeutic efficacy of drugs may prove more fruitful than searching for the new ones. Since recent studies show that new cationic derivatives of polyisoprenoid alcohols (APrens) might exhibit augmenting properties, we intend to use them as a component of liposomal drug carriers. In this study we investigate if these compounds do not per se cause untoward effects on the living organism. Methods: Male Sprague-Dawley rats received for four weeks daily injections (0.5 ml sc) of liposomes built of dioleoyl phosphatidylethanolamine (DOPE), liposomes built of DOPE and APren-7 (ratio 10:1) or water solvent. Weekly, rats were observed in metabolic cages (24 h); blood and urine were sampled for analysis; body weight (BW) and systolic blood pressure (SBP) were determined. After chronic experiment, kidneys and heart were harvested for histological and morphometric analysis. Results: The 4-week BW increments were in the range of 97 +/- 4 to 102 +/- 4\%, intergroup differences were not significant. Microalbuminuria was the lowest in the group receiving liposomes with APren-7 (0.22 +/- 0.03 mg/day). Water and food intake, plasma and urine parameters were similar in all groups. Conclusions: Newly designed liposomes containing APren-7 did not affect functions of the excretory and cardiovascular systems, and renal morphology; therefore we find them suitable as a component of liposomal drug carriers. (C) 2014 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved.
Cechy publikacji
ORIGINAL_ARTICLE
Inne
System-identifier
592469
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