Towards neural correlates of auditory stimulus processing: a simultaneous auditory evoked potentials and functional magnetic resonance study using an odd-ball paradigm
PBN-AR
Instytucja
Instytut Fizjologii i Patologii Słuchu
Informacje podstawowe
Główny język publikacji
angielski
Czasopismo
Medical Science Monitor
ISSN
1234-1010
EISSN
Wydawca
DOI
URL
Rok publikacji
2014
Numer zeszytu
Strony od-do
35-46
Numer tomu
20
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Open access
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Creative Commons — Uznanie autorstwa-Niekomercyjne-Bez utworów zależnych
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Streszczenia
Język
angielski
Treść
BACKGROUND: The neural underpinnings of auditory information processing have often been investigated using the odd-ball paradigm, in which infrequent sounds (deviants) are presented within a regular train of frequent stimuli (standards). Traditionally, this paradigm has been applied using either high temporal resolution (EEG) or high spatial resolution (fMRI, PET). However, used separately, these techniques cannot provide information on both the location and time course of particular neural processes. The goal of this study was to investigate the neural correlates of auditory processes with a fine spatio-temporal resolution. A simultaneous auditory evoked potentials (AEP) and functional magnetic resonance imaging (fMRI) technique (AEP-fMRI), together with an odd-ball paradigm, were used. MATERIAL AND METHODS: Six healthy volunteers, aged 20-35 years, participated in an odd-ball simultaneous AEP-fMRI experiment. AEP in response to acoustic stimuli were used to model bioelectric intracerebral generators, and electrophysiological results were integrated with fMRI data. RESULTS: fMRI activation evoked by standard stimuli was found to occur mainly in the primary auditory cortex. Activity in these regions overlapped with intracerebral bioelectric sources (dipoles) of the N1 component. Dipoles of the N1/P2 complex in response to standard stimuli were also found in the auditory pathway between the thalamus and the auditory cortex. Deviant stimuli induced fMRI activity in the anterior cingulate gyrus, insula, and parietal lobes. CONCLUSIONS: The present study showed that neural processes evoked by standard stimuli occur predominantly in subcortical and cortical structures of the auditory pathway. Deviants activate areas non-specific for auditory information processing.
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System-identifier
PX-56b45b088106eb71826df499
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