Reduced resting-state brain activity in the default mode network in children with (central) auditory processing disorders
PBN-AR
Instytucja
Instytut Fizjologii i Patologii Słuchu
Informacje podstawowe
Główny język publikacji
angielski
Czasopismo
Behavioral and Brain Functions
ISSN
1744-9081
EISSN
Wydawca
DOI
URL
Rok publikacji
2014
Numer zeszytu
Strony od-do
33
Numer tomu
10(1)
Identyfikator DOI
Liczba arkuszy
Open access
Tryb otwartego dostępu
Inne
Wersja tekstu w otwartym dostępie
Licencja otwartego dostępu
Inna
Czas opublikowania w otwartym dostępie
Streszczenia
Język
angielski
Treść
BACKGROUND: In recent years, there has been a growing interest in Central Auditory Processing Disorder (C)APD. However, the neural correlates of (C)APD are poorly understood. Previous neuroimaging experiments have shown changes in the intrinsic activity of the brain in various cognitive deficits and brain disorders. The present study investigated the spontaneous brain activity in (C)APD subjects with resting-state fMRI (rs-fMRI). METHODS: Thirteen children diagnosed with (C)APD and fifteen age and gender-matched controls participated in a rs-fMRI study during which they were asked to relax keeping their eyes open. Two different techniques of the rs-fMRI data analysis were used: Regional Homogeneity (ReHo) and Independent Component Analysis (ICA), which approach is rare. RESULTS: Both methods of data analysis showed comparable results in the pattern of DMN activity within groups. Additionally, ReHo analysis revealed increased co-activation of the superior frontal gyrus, the posterior cingulate cortex/the precuneus in controls, compared to the (C)APD group. ICA yielded inconsistent results across groups. CONCLUSIONS: Our ReHo results suggest that (C)APD children seem to present reduced regional homogeneity in brain regions considered a part of the default mode network (DMN). These findings might contribute to a better understanding of neural mechanisms of (C)APD.
Inne
System-identifier
PX-56b45b078106eb71826df46b
CrossrefMetadata from Crossref logo
Cytowania
Liczba prac cytujących tę pracę
Brak danych
Referencje
Liczba prac cytowanych przez tę pracę
Brak danych