Earliest effects of sudden occlusions on pressure profiles in selected locations of the human systemic arterial system
PBN-AR
Instytucja
Instytut Fizyki Jądrowej im. Henryka Niewodniczańskiego Polskiej Akademii Nauk
Źródłowe zdarzenia ewaluacyjne
Informacje podstawowe
Główny język publikacji
en
Czasopismo
PHYSICAL REVIEW E (35pkt w roku publikacji)
ISSN
2470-0045
EISSN
2470-0053
Wydawca
DOI
URL
Rok publikacji
2017
Numer zeszytu
Strony od-do
032414
Numer tomu
95
Identyfikator DOI
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Autorzy
Pozostali autorzy
+ 2
Słowa kluczowe
en
ACUTE LIMB ISCHEMIA
PULSE-WAVE PROPAGATION
BLOOD-FLOW
WALL MECHANICS
MODELS
SIMULATIONS
THROMBOSIS
BEHAVIOR
OUTCOMES
NETWORK
Streszczenia
Język
en
Treść
We have developed a numerical simulation method for predicting the time dependence (wave form) of pressure at any location in the systemic arterial system in humans. The method uses the matlab-Simulink environment. The input data include explicitly the geometry of the arterial tree, treated up to an arbitrary bifurcation level, and the elastic properties of arteries as well as rheological parameters of blood. Thus, the impact of anatomic details of an individual subject can be studied. The method is applied here to reveal the earliest stages of mechanical reaction of the pressure profiles to sudden local blockages (thromboses or embolisms) of selected arteries. The results obtained with a purely passive model provide reference data indispensable for studies of longer-term effects due to neural and humoral mechanisms. The reliability of the results has been checked by comparison of two available sets of anatomic, elastic, and rheological data involving (i) 55 and (ii) 138 arterial segments. The remaining arteries have been replaced with the appropriate resistive elements. Both models are efficient in predicting an overall shift of pressure, whereas the accuracy of the 55-segment model in reproducing the detailed wave forms and stabilization times turns out dependent on the location of the blockage and the observation point.
Cechy publikacji
peer-reviewed
original-article
Inne
System-identifier
125
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