Nb-C nanocomposite films with enhanced biocompatibility and mechanical properties for hard-tissue implant applications
PBN-AR
Instytucja
Centrum Nanobiomedyczne (Uniwersytet im. Adama Mickiewicza w Poznaniu)
Źródłowe zdarzenia ewaluacyjne
Informacje podstawowe
Główny język publikacji
en
Czasopismo
ACS Applied Materials & Interfaces
ISSN
1944-8244
EISSN
Wydawca
AMER CHEMICAL SOC
DOI
URL
Rok publikacji
2015
Numer zeszytu
11
Strony od-do
6351-6358
Numer tomu
7
Identyfikator DOI
Liczba arkuszy
Słowa kluczowe
en
Alkalinity
Amorphous carbon
Amorphous films
Biocompatibility
Carbon
Carbon films
Corrosion resistance
Diamond like carbon films
Friction
Mechanical properties
Nanocomposites
Nanotechnology
Niobium
Osteoblasts
Phosphatases
Surface chemistry
Thin films
Alkaline phosphatase activity
Biomedical fields
Diamond like carbon
Enhanced adhesions
Hard tissue implants
Low coefficient of friction
Orthopedic implant
Surface techniques
Nanocomposite films
artificial membrane
biomaterial
bone prosthesis
carbon
nanocomposite
niobium
3T3 cell line
animal
artificial membrane
bone prosthesis
cell proliferation
cell survival
chemistry
compressive strength
cytology
hardness
materials testing
mouse
osteoblast
physiology
surface property
synthesis
tensile strength
ultrastructure
Young modulus
3T3 Cells
Animals
Biocompatible Materials
Bone Substitutes
Carbon
Cell Proliferation
Cell Survival
Compressive Strength
Elastic Modulus
Hardness
Materials Testing
Membranes
Artificial
Mice
Nanocomposites
Niobium
Osteoblasts
Surface Properties
Tensile Strength
Streszczenia
Język
en
Treść
One of the key challenges in engineering of orthopedic implants is to "bioactivate" their surface by using different surface techniques and materials. Carbon, especially amorphous (a-C) and diamond-like carbon down (DLC) films have attracted much attention in biomedical fields due to their biocompatibility and low coefficient of friction. However, they are unsuitable for uses as a "bioactivity enhancer" of orthopedic implants due to their bioinertness. In this work, we use the nonreactive magnetron sputtering technique to produce a-C films including the biocompatible niobium (Nb) element to alter the surface chemistry and nanotopography of the a-C films with the purpose of bioactivating the a-C film coated implants. Results show that the nanocomposite films (Nb-C) formed by the addition of Nb into the a-C films not only have improved corrosion resistance, but also possess enhanced mechanical properties (nanohardness, Youngs modulus and superelastic recovery). Preosteoblasts (MC3T3-E1) cultured on the Nb-C films have enhanced adhesion and upregulated alkaline phosphatase (ALP) activity, compared to those cultured on the a-C film and TiO2 films used as a control, which are thought to be ascribed to the combined effects of the changes in surface chemistry and the refinement of the nanotopography caused by the addition of Nb. © 2015 American Chemical Society.
Cechy publikacji
Original article
Original article presents the results of original research or experiment.
Oryginalny artykuł naukowy
Oryginalny artykuł naukowy przedstawia rezultaty oryginalnych badań naukowych lub eksperymentu.
Inne
System-identifier
PBN-R:873953
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