Pulmonary Function Abnormalities in Regard to Age at the Time of Diagnosis of Hypersensitivity Pneumonitis
PBN-AR
Instytucja
Instytut Matki i Dziecka
Źródłowe zdarzenia ewaluacyjne
Książka
Tytuł książki
Respiratory Health
Data publikacji
2015
ISBN
978-3-319-18792-1
Wydawca
Springer International Publishing
Publikacja
Główny język publikacji
en
Tytuł rozdziału
Pulmonary Function Abnormalities in Regard to Age at the Time of Diagnosis of Hypersensitivity Pneumonitis
Rok publikacji
2015
Strony (od-do)
75-84
Numer rozdziału
Identyfikator DOI
Liczba arkuszy
0,5
Hasło encyklopedyczne
Autorzy
(liczba autorów: 9)
Pozostali autorzy
+ 8
Słowa kluczowe
en
Bird fancier’s lung
Diffusion capacity
Extrinsic allergic alveolitis
Interstitial lung disease
Lung disease
Pulmonary function
Total lung capacity
Redaktorzy
(liczba redaktorów: 5)
Pozostali redaktorzy
+ 5
Streszczenia
Język
en
Treść
Hypersensitivity pneumonitis (HP) is a complex syndrome caused by exaggerated immune response to inhalation of a variety of organic particles in susceptible individuals. In this study we assessed the relationship between age at the time of diagnosis and the degree of functional and radiological changes in HP. The diagnosis of HP was made on the basis of a combination of clinical symptoms, medical history, serological tests, radiologic evidence of diffuse lung disease, and absence of other identifiable causes of lung disease. We reviewed the records of 111 patients (68 women) diagnosed with HP over a period of 18 years (1995-2013). The patients were stratified into 3 age-groups: <30, 30-49, and ≥50 years old. The commonest cause of HP was avian antigens (56.8 %). Dyspnea was present in 97.3 % of patients, weight loss in 54.7 % of patients, and respiratory insufficiency in 24.3 % of patients. Lung fibrosis in chest computed tomography was found in 35.1 % of patients. Lung function was impaired more seriously in the youngest age-group, with lung diffusing capacity for carbon monoxide (DLCO) <40 % in 69.2 % of these patients. Restrictive pattern was present in 92.3 % of patients in this group, as compared with the 41.0 % in the whole cohort. In this group, desaturation in the six minute walk test also was most notable, amounting to a median of 11 %. In conclusion, diagnosis of HP at young age is predictive of a more severe clinical course of disease, with lung fibrosis and higher disturbances in pulmonary function.
Cechy publikacji
CHAPTER_IN_A_BOOK
Inne
System-identifier
693202
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